Phenotypes of Motor Deficit and Pain after Experimental Spinal Cord Injury.

ABSTRACT: Motor disability is a common outcome of spinal cord injury (SCI). The recovery of motor function after injury depends on the severity of neurotrauma; motor deficit can be reversible, at least partially, due to the innate tissue capability to recover, which, however, deteriorates with age. Pain is often a comorbidity of injury, although its prediction remains poor. It is largely unknown whether pain can attend motor dysfunction. Here, we implemented SCI for modelling severe and moderate neurotrauma and monitored SCI rats for up to 5 months post-injury to determine the profiles of both motor deficit and nociceptive sensitivity. Our data showed that motor dysfunction remained persistent after a moderate SCI in older animals (5-month-old); however, there were two populations among young SCI ra

SUBMITTER: Krotov V 

PROVIDER: S-EPMC9220047 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature