Predicting High Blood Pressure Using DNA Methylome-Based Machine Learning Models.
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ABSTRACT:
SUBMITTER: Nguyen TM
PROVIDER: S-EPMC9220060 | biostudies-literature | 2022 Jun
REPOSITORIES: biostudies-literature
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Predicting High Blood Pressure Using DNA Methylome-Based Machine Learning Models.
Nguyen Thi Mai TM Le Hoang Long HL Hwang Kyu-Baek KB Hong Yun-Chul YC Kim Jin Hee JH
Biomedicines 20220614 6
DNA methylation modification plays a vital role in the pathophysiology of high blood pressure (BP). Herein, we applied three machine learning (ML) algorithms including deep learning (DL), support vector machine, and random forest for detecting high BP using DNA methylome data. Peripheral blood samples of 50 elderly individuals were collected three times at three visits for DNA methylome profiling. Participants who had a history of hypertension and/or current high BP measure were considered to ha ...[more]
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