Epigenetic-Mediated Antimicrobial Resistance: Host versus Pathogen Epigenetic Alterations.

ABSTRACT: Since the discovery of antibiotics, humans have been benefiting from them by decreasing the morbidity and mortality associated with bacterial infections. However, in the past few decades, misuse of antibiotics has led to the emergence of bacterial infections resistant to multiple drugs, a significant health concern. Bacteria exposed to inappropriate levels of antibiotics lead to several genetic changes, enabling them to survive in the host and become more resistant. Despite the understanding and targeting of genetic-based biochemical changes in the bacteria, the increasing levels of antibiotic resistance are not under control. Many reports hint at the role of epigenetic modifications in the bacterial genome and host epigenetic reprogramming due to interaction with resistant pathogens. Epig

SUBMITTER: Muhammad JS 

PROVIDER: S-EPMC9220109 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature