Urinary Tract Infections Impair Adult Hippocampal Neurogenesis.

ABSTRACT: Previous studies have suggested a link between urinary tract infections (UTIs) and cognitive impairment. One possible contributing factor for UTI-induced cognitive changes that has not yet been investigated is a potential alteration in hippocampal neurogenesis. In this study, we aim to investigate the effect of UTI on brain plasticity by specifically examining alterations in neurogenesis. Adult male Sprague Dawley rats received an intra-urethral injection of an Escherichia coli (E. coli) clinical isolate (10⁸ CFU/mL). We found that rats with a UTI (CFU/mL ≥ 10⁵) had reduced proliferation of neural stem cells (NSCs) at an early time point post infection (day 4) and neurogenesis at a later time point (day 34). This was associated with the decreased express

SUBMITTER: Darwish B 

PROVIDER: S-EPMC9220213 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature