Fingertip-Measured Skin Carotenoids and Advanced Glycation End Product Levels in Glaucoma.

ABSTRACT: Carotenoids have antioxidant properties, and the accumulation of advanced glycation end products (AGEs) is associated with reactive oxygen species production; they have attracted attention as factors predictive of the onset and progression in glaucoma. Fingertip measurement is applicable for carotenoids and AGEs due to its noninvasiveness and simplicity. The study included 663 eyes of 663 Japanese subjects (357 males, 306 females). The mean age was 69.9 years with a standard deviation of 11.0. The study population comprised participants with primary open-angle glaucoma (PG) (n = 358), exfoliation glaucoma (EG) (n = 168), and controls (n = 137). Multivariate models suggested that lower skin carotenoid (SC) levels were associated with male gender (standard β = -0.14), AG

SUBMITTER: Kadoh Y 

PROVIDER: S-EPMC9220224 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature