A Histology-Guided Approach to the Management of Patients with Lupus Nephritis: Are We There Yet?

ABSTRACT: Renal involvement is a frequent complication of systemic lupus erythematosus (SLE). It occurs in up to two-thirds of patients, often early during the disease course, and is the most important predictor of the morbidity and mortality of SLE patients. Despite tremendous improvements in the approach of the lupus nephritis (LN) therapy, including the recent approval of two new disease-modifying therapies, up to 50% of patients do not obtain a renal response and up to 25% will eventually progress to end-stage renal disease (ESRD) within 10 years of diagnosis. Given the lack of correlation between clinical features and histological lesions, there is an increasing need for a histology-guided approach to the management of patients with LN. Apart from the initial diagnosis of type and severity of r

SUBMITTER: Obrisca B 

PROVIDER: S-EPMC9220241 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature