Enhancing Prednisone-Based Arthritis Therapy with Targeted IL-27 Gene Delivery.

ABSTRACT: Rheumatoid arthritis (RA) is a chronic autoimmune disease which is characterized primarily by synovial hyperplasia and accumulation of several types of immune infiltrates that promote progressive destruction of the articular structure. Glucocorticoids are often prescribed to treat RA because of their strong anti-inflammatory and immunosuppressive effects. However, their application must be limited to the short-term due to a risk of adverse events. In the present study, we examined the potential combination of low-dose prednisone with gene delivery of an agent of promising and complementary effectiveness in RA, interleukin (IL)-27. IL-27 has been shown to have anti-inflammatory potential, while also acting as an effective bone-normalization agent in prior reports. The present report examine

SUBMITTER: Marin AA 

PROVIDER: S-EPMC9220267 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature