Local and Systemic Oxidative Stress Biomarkers for Male Infertility: The ORION Study.

ABSTRACT: Infertility problems occur in around 10% of all couples worldwide, with male-factor infertility as the sole contributor in 20-30% of these cases. Oxidative stress (OS) is suggested to be associated with the pathophysiology of male infertility. In spermatozoa, OS can lead to damage to the cell membrane, resulting in disruption of DNA integrity and a decrease in motility. Established biomarkers for OS include free thiols and malondialdehyde (MDA), both representing different components of the reactive species interactome (RSI). This exploratory study aimed to investigate seminal plasma-free thiol and MDA levels in relation to semen parameters as defined by the World Health Organization (WHO) to determine if these markers are adequate to define local OS status. Furthermore, this study investi

SUBMITTER: Bergsma AT 

PROVIDER: S-EPMC9220279 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature