Identification of Novel Vascular Genes Downstream of Islet2 and Nr2f1b Transcription Factors.

ABSTRACT: The genetic regulation of vascular development is not elucidated completely. We previously characterized the transcription factors Islet2 (Isl2) and Nr2f1b as being critical for vascular growth. In this study, we further performed combinatorial microarrays to identify genes that are potentially regulated by these factors. We verified the changed expression of several targets in isl2/nr2f1b morphants. Those genes expressed in vessels during embryogenesis suggested their functions in vascular development. We selectively assayed a potential target follistatin a (fsta). Follistatin is known to inhibit BMP, and BMP signaling has been shown to be important for angiogenesis. However, the fsta's role in vascular development has not been well studied. Here, we showed the vascul

SUBMITTER: Li RF 

PROVIDER: S-EPMC9220758 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature