Nomogram to Predict Cognitive State Improvement after Deep Brain Stimulation for Parkinson's Disease.

ABSTRACT:

Purpose

Parkinson's disease (PD) is a common neurodegenerative disease, for which cognitive impairment is a non-motor symptom (NMS). Bilateral subthalamic nucleus deep brain stimulation (STN-DBS) is an effective treatment for PD. This study established a nomogram to predict cognitive improvement rate after STN-DBS in PD patients.

Methods

We retrospectively analyzed 103 PD patients who underwent STN-DBS. Patients were followed up to measure improvement in MoCA scores one year after surgery. Univariate and multivariate logistic regression analyses were used to identify factors affecting improvement in cognitive status. A nomogram was developed to predict this factor. The discrimination and fitting performance were evaluated by receiver operating characteristics (ROC) analysis,

SUBMITTER: Chang B 

PROVIDER: S-EPMC9220903 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature