Placental dysfunction influences fetal monocyte subpopulation gene expression in preterm birth.

ABSTRACT: The placenta is the primary organ for immune regulation, nutrient delivery, gas exchange, protection against environmental toxins, and physiologic perturbations during pregnancy. Placental inflammation and vascular dysfunction during pregnancy are associated with a growing list of prematurity-related complications. The goal of this study was to identify differences in gene expression profiles in fetal monocytes - cells that persist and differentiate postnatally - according to distinct placental histologic domains. Here, by using bulk RNA-Seq, we report that placental lesions are associated with gene expression changes in fetal monocyte subsets. Specifically, we found that fetal monocytes exposed to acute placental inflammation upregulate biological processes related to monocyte activation,

SUBMITTER: Sharma AM 

PROVIDER: S-EPMC9220934 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature