Pretransplant Systemic Lipidomic Profiles in Allogeneic Stem Cell Transplant Recipients.

ABSTRACT: Allogeneic stem cell transplantation is used in the treatment of high-risk hematological malignancies. However, this treatment is associated with severe treatment-related morbidity and mortality. The metabolic status of the recipient may be associated with the risk of development of transplant-associated complications such as graft-versus-host disease (GVHD). To better understand the impact of the lipidomic profile of transplant recipients on posttransplant complications, we evaluated the lipid signatures of patients with hematological disease using non-targeted lipidomics. In the present study, we studied pretransplant serum samples derived from 92 consecutive patients with acute myeloid leukemia (AML) or high-risk myelodysplastic syndrome (MDS). A total of 960 lipid biochemicals were ide

SUBMITTER: Hatfield KJ 

PROVIDER: S-EPMC9220974 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature