Plasma metabolites associated with chronic kidney disease and renal function in adults from the Baltimore Longitudinal Study of Aging.

ABSTRACT:

Introduction

Chronic kidney disease (CKD) is an important cause of disability and death, but its pathogenesis is poorly understood. Plasma metabolites can provide insights into underlying processes associated with CKD.

Objectives

To clarify the relationship of plasma metabolites with CKD and renal function in human.

Methods

We used a targeted metabolomics approach to characterize the relationship of 450 plasma metabolites with CKD and estimated glomerular filtration rate (eGFR) in 616 adults, aged 38-94 years, who participated in the Baltimore Longitudinal Study of Aging.

Results

There were 74 (12.0%) adults with CKD. Carnitine, acetylcarnitine, propionylcarnitine, butyrylcarnitine, trigonelline, trimethylamine N-oxide (TMAO), 1-methylhistidine, citrulline, hom

SUBMITTER: Yamaguchi Y 

PROVIDER: S-EPMC9220986 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature