Unexpected Effect of IL-1β on the Function of GABA_A Receptors in Pediatric Focal Cortical Dysplasia.

ABSTRACT: Focal cortical dysplasia (FCD) type II is an epileptogenic malformation of the neocortex, as well as a leading cause of drug-resistant focal epilepsy in children and young adults. The synaptic dysfunctions leading to intractable seizures in this disease appear to have a tight relationship with the immaturity of GABAergic neurotransmission. The likely outcome would include hyperpolarizing responses upon activation of GABA_ARs. In addition, it is well-established that neuroinflammation plays a relevant role in the pathogenesis of FCD type II. Here, we investigated whether IL-1β, a prototypical pro-inflammatory cytokine, can influence GABAergic neurotransmission in FCD brain tissues. To this purpose, we carried out electrophysiological recordings on Xenopus oocytes transplant

SUBMITTER: Alfano V 

PROVIDER: S-EPMC9220988 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature