Inverse Association between Statin Use and Cancer Mortality Relates to Cholesterol Level.

ABSTRACT: Statins have been associated with a decreased cancer mortality. However, cholesterol level as such may modify the risk of cancer death. To clarify the complex interplay between statins, cholesterol level, and cancer mortality, we conducted a comprehensive analysis to separate the effects of cholesterol level and statin medication on cancer mortality. Our study population consisted of 16,924 men participating in the Finnish Randomized Study of Screening for Prostate Cancer with at least one cholesterol measurement during follow-up (1996-2017). Cox proportional regression was used to estimate hazard ratios. In total, 1699 cancer deaths were observed during the median follow-up of 19 years. When statins' association with the risk of cancer death was estimated without adjustment for cholestero

SUBMITTER: Peltomaa AI 

PROVIDER: S-EPMC9221017 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature