Sulfonamide-Derived Dithiocarbamate Gold(I) Complexes Induce the Apoptosis of Colon Cancer Cells by the Activation of Caspase 3 and Redox Imbalance.

ABSTRACT: Two new families of dithiocarbamate gold(I) complexes derived from benzenesulfonamide with phosphine or carbene as ancillary ligands have been synthesized and characterized. In the screening of their in vitro activity on human colon carcinoma cells (Caco-2), we found that the more lipophilic complexes-those with the phosphine PPh₃-exhibited the highest anticancer activity whilst also displaying significant cancer cell selectivity. [Au(S₂CNHSO₂C₆H₅)(PPh₃)] (1) and [Au(S₂CNHSO₂-p-Me-C₆H₄)(IMePropargyl)] (8) produce cell death, probably by intrinsic apoptosis (mitochondrial membrane potential modification) and caspase 3 activation, causing cell cycle arrest in the G1 pha

SUBMITTER: Quero J 

PROVIDER: S-EPMC9221018 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature