Critical Requirements for the Initiation of a Cardiac Arrhythmia in Rat Ventricle: How Many Myocytes?

ABSTRACT: Cardiovascular disease is the leading cause of death worldwide due in a large part to arrhythmia. In order to understand how calcium dynamics play a role in arrhythmogenesis, normal and dysfunctional Ca²⁺ signaling in a subcellular, cellular, and tissued level is examined using cardiac ventricular myocytes at a high temporal and spatial resolution using multiscale computational modeling. Ca²⁺ sparks underlie normal excitation-contraction coupling. However, under pathological conditions, Ca²⁺ sparks can combine to form Ca²⁺ waves. These propagating elevations of (Ca²⁺)_i can activate an inward Na⁺-Ca²⁺ exchanger current (I_NCX) that contributes to early after-depolarization (EADs) and delayed af

SUBMITTER: Ullah A 

PROVIDER: S-EPMC9221049 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature