Salivary Proteomics Markers for Preclinical Sjogren's Syndrome: A Pilot Study.

ABSTRACT: Primary Sjögren's syndrome (pSS) is a complex autoimmune disorder that particularly affects the salivary and lachrymal glands, generally causing a typical dryness of the eyes and of the mouth. The disease encompasses diverse clinical representations and is characterized by B-cell polyclonal activation and autoantibodies production, including anti-Ro/SSA. Recently, it has been suggested that autoantibody profiling may enable researchers to identify susceptible asymptomatic individuals in a pre-disease state. In this pilot study, we used mass spectrometry to analyze and compare the salivary proteomics of patients with established pSS and patients with pre-clinical SS, identifying a common protein signature in their salivary fluid. We found that several inflammatory, immunity-related, and typ

SUBMITTER: Di Giorgi N 

PROVIDER: S-EPMC9221050 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature