Context-Dependent Effects Explain Divergent Prognostic Roles of Tregs in Cancer.

ABSTRACT: Assessing cancer prognosis is a challenging task, given the heterogeneity of the disease. Multiple features (clinical, environmental, genetic) have been used for such assessments. The tumor immune microenvironment (TIME) is a key feature, and describing the impact of its many components on cancer prognosis is an active field of research. The complexity of the tumor microenvironment context makes it difficult to use the TIME to assess prognosis, as demonstrated by the example of regulatory T cells (Tregs). The effect of Tregs on prognosis is ambiguous, with different studies considering them to be negative, positive or neutral. We focused on five different cancer types (breast, colorectal, gastric, lung and ovarian). We clarified the definition of Tregs and their utility for assessing cance

SUBMITTER: Amblard E 

PROVIDER: S-EPMC9221270 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature