Genes Responsible for H₂S Production and Metabolism Are Involved in Learning and Memory in Drosophila melanogaster.

ABSTRACT: The gasotransmitter hydrogen sulfide (H₂S) produced by the transsulfuration pathway (TSP) is an important biological mediator, involved in many physiological and pathological processes in multiple higher organisms, including humans. Cystathionine-β-synthase (CBS) and cystathionine-γ-lyase (CSE) enzymes play a central role in H₂S production and metabolism. Here, we investigated the role of H₂S in learning and memory processes by exploring several Drosophila melanogaster strains with single and double deletions of CBS and CSE developed by the CRISPR/Cas9 technique. We monitored the learning and memory parameters of these strains using the mating rejection courtship paradigm and demonstrated that the deletion of the CBS gene, which is expressed p

SUBMITTER: Zatsepina OG 

PROVIDER: S-EPMC9221306 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature