Complex Role of Microbiome in Pancreatic Tumorigenesis: Potential Therapeutic Implications.

ABSTRACT: Pancreatic cancer (PC) is the fourth leading cause of cancer-related mortality with limited diagnostic and therapeutic options. Although immunotherapy has shown promise in the treatment of several cancers, its role in pancreatic cancer is rather limited. Several studies have focused on determining the role of the tumor microenvironment with cancer-cell-intrinsic events and tumor-infiltrating immune cellular properties. However, in the past decade, there has been emerging research aimed at delineating the role of the host microbiome, including the metabolites from microbes and host responses, on pancreatic tumorigenesis. Importantly, there is emerging evidence suggesting the beneficial role of a gut microbiome transplant to improve immunotherapeutic outcomes in cancer patients. In this revi

SUBMITTER: Amara S 

PROVIDER: S-EPMC9221309 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature