Ultrasound-Mediated Bioeffects in Senescent Mice and Alzheimer's Mouse Models.

ABSTRACT: Ultrasound is routinely used for a wide range of diagnostic imaging applications. However, given that ultrasound can operate over a wide range of parameters that can all be modulated, its applicability extends far beyond the bioimaging field. In fact, the modality has emerged as a hybrid technology that effectively assists drug delivery by transiently opening the blood-brain barrier (BBB) when combined with intravenously injected microbubbles, and facilitates neuromodulation. Studies in aged mice contributed to an insight into how low-intensity ultrasound brings about its neuromodulatory effects, including increased synaptic plasticity and improved cognitive functions, with a potential role for neurogenesis and the modulation of NMDA receptor-mediated neuronal signalling. This work is comp

SUBMITTER: Balbi M 

PROVIDER: S-EPMC9221310 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature