Severe Radiation-Induced Lymphopenia Affects the Outcomes of Esophageal Cancer: A Comprehensive Systematic Review and Meta-Analysis.

ABSTRACT: The aim of the current study was to evaluate the influence of severe radiation-induced lymphopenia (RIL) on the outcomes of esophageal cancer (EC). A systematic review and meta-analysis was performed through the PRISMA guideline. Seventeen studies were included in the current systematic review, with eight included in the meta-analyses. Meta-analyses found that severe RIL was associated with lower pathologic complete response (pCR) rate (odds ratio (OR) = 0.44, 95% confidence interval (CI) = 0.30-0.66, I² = 0%), inferior overall survival (OS) (hazard ratio (HR) = 1.50, 95% CI = 1.29-1.75, I² = 6%), and worse progression-free survival (PFS) (HR = 1.70, 95% CI = 1.39-2.07, I² = 0%) of EC patients. The lymphocyte nadir was found during 4-6 weeks after the start

SUBMITTER: Dai D 

PROVIDER: S-EPMC9221375 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature