Ontology highlight
ABSTRACT:
SUBMITTER: Messina M
PROVIDER: S-EPMC9221405 | biostudies-literature | 2022 Jun
REPOSITORIES: biostudies-literature
Messina Monica M Piciocchi Alfonso A Ottone Tiziana T Paolini Stefania S Papayannidis Cristina C Lessi Federica F Fracchiolla Nicola Stefano NS Forghieri Fabio F Candoni Anna A Mengarelli Andrea A Martelli Maria Paola MP Venditti Adriano A Carella Angelo Michele AM Albano Francesco F Mancini Valentina V Massimo Bernardi B Arena Valentina V Sargentini Valeria V Sciumè Mariarita M Pastore Domenico D Todisco Elisabetta E Roti Giovanni G Siragusa Sergio S Ladetto Marco M Pravato Stefano S De Bellis Eleonora E Simonetti Giorgia G Marconi Giovanni G Cerchione Claudio C Fazi Paola P Vignetti Marco M Amadori Sergio S Martinelli Giovanni G Voso Maria Teresa MT
Cancers 20220618 12
IDH1/2 mutations are common in acute myeloid leukemia (AML) and represent a therapeutic target. The GIMEMA AML1516 observational protocol was designed to study the prevalence of IDH1/2 mutations and associations with clinico-biological parameters in a cohort of Italian AML patients. We analyzed a cohort of 284 AML consecutive patients at diagnosis, 139 females and 145 males, of a median age of 65 years (range: 19−86). Of these, 38 (14%) harbored IDH1 and 51 (18%) IDH2 mutations. IDH1/2 mutations ...[more]