Structure of New Ferroverdins Recruiting Unconventional Ferrous Iron Chelating Agents.

ABSTRACT: Ferroverdins are ferrous iron (Fe²⁺)-nitrosophenolato complexes produced by a few Streptomyces species as a response to iron overload. Previously, three ferroverdins were identified: ferroverdin A, in which three molecules of p-vinylphenyl-3-nitroso-4-hydroxybenzoate (p-vinylphenyl-3,4-NHBA) are recruited to bind Fe²⁺, and Ferroverdin B and Ferroverdin C, in which one molecule of p-vinylphenyl-3,4-NHBA is substituted by hydroxy-p-vinylphenyl-3,4-NHBA, and by carboxy-p-vinylphenyl-3,4-NHBA, respectively. These molecules, especially ferroverdin B, are potent inhibitors of the human cholesteryl ester transfer protein (CETP) and therefore candidate hits for the development of drugs that increase the serum concentration of high-den

SUBMITTER: Martinet L 

PROVIDER: S-EPMC9221444 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature