Identifying the Potential Roles of PBX4 in Human Cancers Based on Integrative Analysis.

ABSTRACT: PBX4 belongs to the pre-B-cell leukemia homeobox (PBX) transcription factors family and acts as a transcriptional cofactor of HOX proteins participating in several pathophysiological processes. Recent studies have revealed that the dysregulation of PBX4 is closely related to multiple diseases, especially cancers. However, the research on PBX4's potential roles in 33 cancers from the Cancer Genome Atlas (TCGA) is still insufficient. Therefore, we performed a comprehensive pan-cancer analysis to explore the roles of PBX4with multiple public databases. Our results showed that PBX4 was differentially expressed in 17 types of human cancer and significantly correlated to the pathological stage, tumor grade, and immune and molecular subtypes. We used the Kaplan-Meier plotter and PrognoScan databa

SUBMITTER: Song Y 

PROVIDER: S-EPMC9221482 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature