Contribution of the Skin-Gut Axis to Immune-Related Adverse Events with Multi-System Involvement.

ABSTRACT: Immune-related adverse events (irAEs) frequently complicate treatment with immune checkpoint blockade (ICB) targeting CTLA-4, PD-1, and PD-L1, which are commonly used to treat solid and hematologic malignancies. The skin and gastrointestinal (GI) tract are most frequently affected by irAEs. While extensive efforts to further characterize organ-specific adverse events have contributed to the understanding and management of individual toxicities, investigations into the relationship between multi-organ toxicities have been limited. Therefore, we aimed to conduct a characterization of irAEs occurring in both the skin and gut. A retrospective analysis of two cohorts of patients treated with ICB at Memorial Sloan Kettering Cancer Center was conducted, including a cohort of patients with cutaneo

SUBMITTER: Kuo AM 

PROVIDER: S-EPMC9221505 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature