Ontology highlight
ABSTRACT:
SUBMITTER: Abu-Khalaf M
PROVIDER: S-EPMC9221535 | biostudies-literature | 2022 Jun
REPOSITORIES: biostudies-literature
Abu-Khalaf Maysa M Wang Chun C Zhang Zhenchao Z Luo Rui R Chong Weelic W Silver Daniel P DP Fellin Frederick F Jaslow Rebecca R Lopez AnaMaria A Cescon Terrence T Jiang Wei W Myers Ronald R Wei Qiang Q Li Bingshan B Cristofanilli Massimo M Yang Hushan H
Cancers 20220610 12
Previously undescribed molecular mechanisms of resistance will emerge with the increased use of cyclin-dependent kinase 4/6 inhibitors in clinical settings. To identify genomic aberrations in circulating tumor DNA associated with treatment resistance in palbociclib-treated metastatic breast cancer (MBC) patients, we collected 35 pre- and post-treatment blood samples from 16 patients with estrogen receptor-positive (ER<sup>+</sup>) MBC, including 9 with inflammatory breast cancer (IBC). Circulati ...[more]