SARS-CoV-2 Spike mutations modify the interaction between virus Spike and human ACE2 receptors.

ABSTRACT: The high mutability of the SARS-CoV-2 virus is a growing concern among scientific communities and health professionals since it brings the effectiveness of repurposed drugs and vaccines for COVID-19 into question. Although the mutational investigation of the Spike protein of the SARS-CoV-2 virus has been confirmed by many different researchers, there is no thorough investigation carried out at the interacting region to reveal the mutational status and its associated severity. All the energetically favorable mutations and their detailed analytical features that could impact the infection severity of the SARS-CoV-2 virus need to be identified. Therefore, we have thoroughly investigated the most important site of the SARS-CoV-2 virus, which is the interface region (Residue 417-505) of the vir

SUBMITTER: Mishra PM 

PROVIDER: S-EPMC9221686 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature