Deconstructing gastrulation at single-cell resolution.

ABSTRACT: Gastrulation movements in all animal embryos start with regulated deformations of patterned epithelial sheets, which are driven by cell divisions, cell shape changes, and cell intercalations. Each of these behaviors has been associated with distinct aspects of gastrulation^1-4 and has been a subject of intense research using genetic, cell biological, and more recently, biophysical approaches.^5-14 Most of these studies, however, focus either on cellular processes driving gastrulation or on large-scale tissue deformations.^15-23 Recent advances in microscopy and image processing create a unique opportunity for integrating these complementary viewpoints.^24-28 Here, we take a step toward bridging these complementary strategies and deconstruct the early

SUBMITTER: Stern T 

PROVIDER: S-EPMC9221752 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature