Endothelin B Receptor Immunodynamics in Pulmonary Arterial Hypertension.

ABSTRACT:

Introduction

Inflammation is a major pathological feature of pulmonary arterial hypertension (PAH), particularly in the context of inflammatory conditions such as systemic sclerosis (SSc). The endothelin system and anti-endothelin A receptor (ET_A) autoantibodies have been implicated in the pathogenesis of PAH, and endothelin receptor antagonists are routinely used treatments for PAH. However, immunological functions of the endothelin B receptor (ET_B) remain obscure.

Methods

Serum levels of anti-ET_B receptor autoantibodies were quantified in healthy donors and SSc patients with or without PAH. Age-dependent effects of overexpression of prepro-endothelin-1 or ET_B deficiency on pulmonary inflammation and the cardiovascular system were

SUBMITTER: Tabeling C 

PROVIDER: S-EPMC9221837 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature