Patterns of Focal Amyloid Deposition Using ¹⁸F-Florbetaben PET in Patients with Cognitive Impairment.

ABSTRACT: Accumulation of aggregated amyloid-β (Aβ) in the brain is considered the first pathological event within the pathogenesis of Alzheimer's disease (AD). It is difficult to accurately identify the initial brain regions of Aβ accumulation due to the time-lag between the start of the pathophysiology and symptom onset. However, focal regional amyloid uptake on amyloid PET scans may provide insights into this. Hence, we aimed to evaluate the topographic distribution of amyloid deposition in patients with cognitive impairment and to identify the starting order of amyloid accumulation in the brain using conditional probability. We enrolled 58 patients composed of 9 normal cognition (NC), 32 mild cognitive impairment (MCI), and 17 dementia showing focal regional amyloid deposition corresponding to a

SUBMITTER: Chung SE 

PROVIDER: S-EPMC9221882 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature