Performance of Antigen Detection Tests for SARS-CoV-2: A Systematic Review and Meta-Analysis.

ABSTRACT: Coronavirus disease 2019 (COVID-19) initiated global health care challenges such as the necessity for new diagnostic tests. Diagnosis by real-time PCR remains the gold-standard method, yet economical and technical issues prohibit its use in points of care (POC) or for repetitive tests in populations. A lot of effort has been exerted in developing, using, and validating antigen-based tests (ATs). Since individual studies focus on few methodological aspects of ATs, a comparison of different tests is needed. Herein, we perform a systematic review and meta-analysis of data from articles in PubMed, medRxiv and bioRxiv. The bivariate method for meta-analysis of diagnostic tests pooling sensitivities and specificities was used. Most of the AT types for SARS-CoV-2 were lateral flow immunoassays (L

SUBMITTER: Tapari A 

PROVIDER: S-EPMC9221910 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature