Volumetric Analysis of Hearing-Related Structures of Brain in Children with GJB2-Related Congenital Deafness.

ABSTRACT:

Background

Children with non-syndromic hereditary sensorineural hearing loss (SNHL) provide an opportunity to explore the impact of hearing on brain development.

Objective

This study investigates volumetric differences of key hearing-related structures in children with gap junction protein beta 2 GJB2-related SNHL compared to controls.

Materials and methods

Ninety-four children with SNHL (n = 15) or normal hearing (n = 79) were studied using automated volumetric segmentation. Heschl's gyrus (HG), anterior HG (aHG), planum temporale (PT), medial geniculate nucleus (MGN), and nucleus accumbens (NA) were analyzed relative to total brain volume (TBV) at two different age groups: (1) 7-12 months and (2) 13 months-18 years. Two-sided t-tests were used to evalu

SUBMITTER: Wagner MW 

PROVIDER: S-EPMC9222099 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature