Vitamin D Binding Protein and Renal Injury in Acute Decompensated Heart Failure.

ABSTRACT:

Background

Renal function in acute decompensated heart faiulre (ADHF) is a strong predictor of disease evolution and poor outcome. Current biomarkers for early diagnostic of renal injury in the setting of ADHF are still controversial, and their association to early pathological changes needs to be established. By applying a proteomic approach, we aimed to identify early changes in the differential urine protein signature associated with development of renal injury in patients hospitalised due to ADHF.

Materials and methods

Patients (71 [64-77] years old) admitted at the emergency room with ADHF and hospitalised were investigated (N = 64). Samples (urine/serum) were collected at hospital admission (day 0) and 72 h later (day 3). Differential serum proteome was analysed

SUBMITTER: Diaz-Riera E 

PROVIDER: S-EPMC9222131 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature