Longitudinal CSF proteomics identifies NPTX2 as a prognostic biomarker of Alzheimer's disease.

ABSTRACT:

Introduction

Biomarkers that reflect pathologic processes affecting neuronal function during preclinical and early stages of Alzheimer's disease (AD) are needed to aid drug development.

Methods

A targeted, stable isotope, quantitative mass spectrometry-based investigation of longitudinal changes in concentrations of previously identified candidate biomarkers was performed in cerebrospinal fluid (CSF) of Alzheimer's Disease Neuroimaging Initiative participants who were classified as cognitively normal (CN; n = 76) or with mild cognitive impairment (MCI; n = 111) at baseline.

Results

Of the candidate biomarkers, the CSF concentration of neuronal pentraxin 2 (NPTX2), a protein involved in synaptic function, exhibited rates of change that were significantly different betw

SUBMITTER: Libiger O 

PROVIDER: S-EPMC9222372 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature