Unravelling the Supramolecular Driving Forces in the Formation of CO₂-Responsive Pseudopeptidic Low-Molecular-Weight Hydrogelators.

ABSTRACT: A new family of C₂-symmetric pseudopeptides with a high functional density for supramolecular interactions has been synthetized through the attachment of four amino acid subunits to a diamino aliphatic spacer. The resulting open-chain compounds present remarkable properties as low-molecular-weight hydrogelators. The self-assembled 3D networks were characterized by SEM analyses, observing regular nanofibres with 80-100 nm diameters. Spectroscopic and molecular modelling experiments revealed the presence of strong synergic effects between the H-bonding and π-π interactions, with the best results obtained for the homoleptic tetra-pseudopeptide derived from l-Phe. In addition, these bioinspired hydrogels possessed pH- and CO₂-responsive sol-gel transitions. The formation

SUBMITTER: Esteve F 

PROVIDER: S-EPMC9222431 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature