Correlation between Genomic Variants and Worldwide Epidemiology of Prostate Cancer.

ABSTRACT: Prostate cancer (PCa) incidence and mortality vary across territories and populations. This can be explained by the genetic factor of this disease. This article aims to correlate the epidemiological data, worldwide incidence, and mortality of PCa with single-nucleotide polymorphisms (SNPs) associated with the susceptibility and severity of this neoplasm in different populations. Eighty-four genetic variants associated with prostate cancer susceptibility were selected from the literature through genome association studies (GWAS). Allele frequencies were obtained from the 1000 Genomes Project, and epidemiological data were obtained from Surveillance, Epidemiology, and End Results (SEER). The PCa incidence, mortality rates, and allele frequencies of variants were evaluated by Pearson's correl

SUBMITTER: Vieira GM 

PROVIDER: S-EPMC9222668 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature