ILC2s Control Microfilaremia During Litomosoides sigmodontis Infection in Rag2^-/- Mice.

ABSTRACT: Group 2 innate lymphoid cells (ILC2s) are inducers of type 2 immune responses, but their role during filarial infection remains unclear. In the present study, we used the Litomosoides sigmodontis rodent model of filariasis to analyze ILC2s during infection in susceptible BALB/c mice that develop a chronic infection with microfilaremia and semi-susceptible C57BL/6 mice that eliminate the filariae shortly after the molt into adult worms and thus do not develop microfilaremia. ILC2s (CD45⁺ Lineage^- TCRβ^- CD90.2⁺ Sca-1⁺ IL-33R⁺ GATA-3⁺) were analyzed in the pleural cavity, the site of L. sigmodontis infection, after the infective L3 larvae reached the pleural cavity (9 days post infection, dpi), after th

SUBMITTER: Reichwald JJ 

PROVIDER: S-EPMC9222899 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature