Intranasal Delivery of Darunavir-Loaded Mucoadhesive In Situ Gel: Experimental Design, In Vitro Evaluation, and Pharmacokinetic Studies.

ABSTRACT: The clinical efficacy of antiretroviral therapy in NeuroAIDS is primarily limited by the low perfusion of the drug to the brain. The objective of the current investigation was to design and develop an in situ mucoadhesive gel loaded with darunavir to assess the feasibility of brain targeting through the intranasal route. Preliminary batches (F1-F9) were prepared and evaluated for various pharmaceutical characteristics. A full factorial design of the experiment was applied to optimize and assess the effect of two influencing variables (Carbopol 934P (X₁) and Poloxamer 407 (X₂)) on the response effects (gelation temperature (Y₁) and % drug release (Y₂) at 8 h). The data demonstrate that both influencing variables affect the response variables signi

SUBMITTER: Nair AB 

PROVIDER: S-EPMC9223067 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature