Identifying Rare Genetic Variants of Immune Mediators as Risk Factors for Autism Spectrum Disorder.

ABSTRACT: Autism spectrum disorder (ASD) affects more than 1% of children, and there is no viable pharmacotherapeutic agent to treat the core symptoms of ASD. Studies have shown that children with ASD show changes in their levels of immune response molecules. Our previous studies have shown that ASD is more common in children with folate receptor autoantibodies. We also found that children with ASD have abnormal gut immune function, which was characterized by a significant increase in the content of immunoglobulin A and an increase in gut-microbiota-associated epitope diversity. These studies suggest that the immune mechanism plays an important role in the occurrence of ASD. The present study aims to systematically assess gene mutations in immune mediators in patients with ASD. We collected genetic

SUBMITTER: Cai C 

PROVIDER: S-EPMC9223212 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature