SALARECON connects the Atlantic salmon genome to growth and feed efficiency.

ABSTRACT: Atlantic salmon (Salmo salar) is the most valuable farmed fish globally and there is much interest in optimizing its genetics and rearing conditions for growth and feed efficiency. Marine feed ingredients must be replaced to meet global demand, with challenges for fish health and sustainability. Metabolic models can address this by connecting genomes to metabolism, which converts nutrients in the feed to energy and biomass, but such models are currently not available for major aquaculture species such as salmon. We present SALARECON, a model focusing on energy, amino acid, and nucleotide metabolism that links the Atlantic salmon genome to metabolic fluxes and growth. It performs well in standardized tests and captures expected metabolic (in)capabilities. We show that it can explain observe

SUBMITTER: Zakhartsev M 

PROVIDER: S-EPMC9223387 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature