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Harnessing the B Cell Response in Kidney Transplantation - Current State and Future Directions.

ABSTRACT: Despite dramatic improvement in kidney transplantation outcomes over the last decades due to advent of modern immunosuppressive agents, long-term outcomes remain poor. Antibody-mediated rejection (ABMR), a B cell driven process, accounts for the majority of chronic graft failures. There are currently no FDA-approved regimens for ABMR; however, several clinical trials are currently on-going. In this review, we present current mechanisms of B cell response in kidney transplantation, the clinical impact of sensitization and ABMR, the B cell response under current immunosuppressive regimens, and ongoing clinical trials for ABMR and desensitization treatment.

SUBMITTER: Anwar IJ

PROVIDER: S-EPMC9223638 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Harnessing the B Cell Response in Kidney Transplantation - Current State and Future Directions.

Anwar Imran J IJ DeLaura Isabel F IF Gao Qimeng Q Ladowski Joseph J Jackson Annette M AM Kwun Jean J Knechtle Stuart J SJ

Frontiers in immunology 20220609

Despite dramatic improvement in kidney transplantation outcomes over the last decades due to advent of modern immunosuppressive agents, long-term outcomes remain poor. Antibody-mediated rejection (ABMR), a B cell driven process, accounts for the majority of chronic graft failures. There are currently no FDA-approved regimens for ABMR; however, several clinical trials are currently on-going. In this review, we present current mechanisms of B cell response in kidney transplantation, the clinical i ...[more]

PMID: 35757745

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