Cytoplasmic p53β Isoforms Are Associated with Worse Disease-Free Survival in Breast Cancer.

ABSTRACT: TP53 mutations are associated with tumour progression, resistance to therapy and poor prognosis. However, in breast cancer, TP53's overall mutation frequency is lower than expected (~25%), suggesting that other mechanisms may be responsible for the disruption of this critical tumour suppressor. p53 isoforms are known to enhance or disrupt p53 pathway activity in cell- and context-specific manners. Our previous study revealed that p53 isoform mRNA expression correlates with clinicopathological features and survival in breast cancer and may account for the dysregulation of the p53 pathway in the absence of TP53 mutations. Hence, in this study, the protein expression of p53 isoforms, transactivation domain p53 (TAp53), p53β, Δ40p53, Δ133p53 and Δ160p53 was analysed using

SUBMITTER: Steffens Reinhardt L 

PROVIDER: S-EPMC9223648 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature