Quantitative Susceptibility Mapping Using a Multispectral Autoregressive Moving Average Model to Assess Hepatic Iron Overload.

ABSTRACT:

Background

R2*-MRI is clinically used to noninvasively assess hepatic iron content (HIC) to guide potential iron chelation therapy. However, coexisting pathologies, such as fibrosis and steatosis, affect R2* measurements and may thus confound HIC estimations.

Purpose

To evaluate whether a multispectral auto regressive moving average (ARMA) model can be used in conjunction with quantitative susceptibility mapping (QSM) to measure magnetic susceptibility as a confounder-free predictor of HIC.

Study type

Phantom study and in vivo cohort.

Subjects

Nine iron phantoms covering clinically relevant R2* range (20-1200/second) and 48 patients (22 male, 26 female, median age 18 years).

Field strength/sequence

Three-dimensional (3D) and two-dimensional (2D) multi-ec

SUBMITTER: Tipirneni-Sajja A 

PROVIDER: S-EPMC9223690 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature