Risk of Anorectal Cancer Associated with Benign Anal Inflammatory Diseases: A Retrospective Matched Cohort Study.

ABSTRACT:

Purpose

The purpose of our study was to evaluate the relationship between benign anal inflammatory diseases and anorectal cancer and assess its risk factors.

Methods

A retrospective matched cohort study was conducted that included data from 2002 to 2013. The National Health Insurance Service National Sample Cohort data from 2002 to 2013 was used for the study. Of a total study population of 143,884 individuals, 28,110 individuals with anal fissures were assigned to the case group, while 115,774 individuals without anal fissures were assigned to the control group based on the 1:4 propensity score matching age, sex, and year (case: diagnosed year, control: health service received year).

Results

The risk of anorectal cancer was higher in the case group (hazard ratio [HR]

SUBMITTER: Chae W 

PROVIDER: S-EPMC9223752 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature