Reconstruction of Full-Length circRNA Sequences Using Chimeric Alignment Information.

ABSTRACT: Circular RNAs (circRNAs) are RNA molecules formed by joining a downstream 3 splice donor site and an upstream 5 splice acceptor site. Several recent studies have identified circRNAs as potential biomarker for different diseases. A number of methods are available for the identification of circRNAs. The circRNA identification methods cannot provide full-length sequences. Reconstruction of the full-length sequences is crucial for the downstream analyses of circRNA research including differential expression analysis, circRNA-miRNA interaction analysis and other functional studies of the circRNAs. However, a limited number of methods are available in the literature for the reconstruction of full-length circRNA sequences. We developed a new method, circRNA-full, for full-length circRNA sequence

SUBMITTER: Hossain MT 

PROVIDER: S-EPMC9223815 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature