RtcB2-PrfH Operon Protects E. coli ATCC25922 Strain from Colicin E3 Toxin.

ABSTRACT: In the bid to survive and thrive in an environmental setting, bacterial species constantly interact and compete for resources and space in the microbial ecosystem. Thus, they have adapted to use various antibiotics and toxins to fight their rivals. Simultaneously, they have evolved an ability to withstand weapons that are directed against them. Several bacteria harbor colicinogenic plasmids which encode toxins that impair the translational apparatus. One of them, colicin E3 ribotoxin, mediates cleavage of the 16S rRNA in the decoding center of the ribosome. In order to thrive upon deployment of such ribotoxins, competing bacteria may have evolved counter-conflict mechanisms to prevent their demise. A recent study demonstrated the role of PrfH and the RtcB2 module in rescuing a damaged ribo

SUBMITTER: Maviza TP 

PROVIDER: S-EPMC9223846 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature