Targeting Breast Cancer Stem Cells Using Naturally Occurring Phytoestrogens.

ABSTRACT: Breast cancer therapies have made significant strides in improving survival for patients over the past decades. However, recurrence and drug resistance continue to challenge long-term recurrence-free and overall survival rates. Mounting evidence supports the cancer stem cell model in which the existence of a small population of breast cancer stem cells (BCSCs) within the tumor enables these cells to evade conventional therapies and repopulate the tumor, giving rise to more aggressive, recurrent tumors. Thus, successful breast cancer therapy would need to target these BCSCs, as well the tumor bulk cells. Since the Women's Health Initiative study reported an increased risk of breast cancer with the use of conventional hormone replacement therapy in postmenopausal women, many have turned thei

SUBMITTER: Nguyen M 

PROVIDER: S-EPMC9224163 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature