Effective Natural Killer Cell Degranulation Is an Essential Key in COVID-19 Evolution.

ABSTRACT: NK degranulation plays an important role in the cytotoxic activity of innate immunity in the clearance of intracellular infections and is an important factor in the outcome of the disease. This work has studied NK degranulation and innate immunological profiles and functionalities in COVID-19 patients and its association with the severity of the disease. A prospective observational study with 99 COVID-19 patients was conducted. Patients were grouped according to hospital requirements and severity. Innate immune cell subpopulations and functionalities were analyzed. The profile and functionality of innate immune cells differ between healthy controls and severe patients; CD56dim NK cells increased and MAIT cells and NK degranulation rates decreased in the COVID-19 subjects. Higher degranulat

SUBMITTER: Garcinuno S 

PROVIDER: S-EPMC9224310 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature